Research Research Highlight The photoelectric chip and soft manipulator were assembled into an optical mechanical interaction system to realize manipulator operation Multimodal intergrated system successfully achieved stimulus recognition and neural-reflex in a rabbit sciatic nerve model by integrating the multimodal sensor signals using a deep learning technique Flexible bio-chip measeures bio-chemicals (protein, amino acid, enzyme, gas molecule, DNA) central to hereditary disease Semiconductor Materials-based intergrated system for Human-Cyber-Physical Systems